منابع مشابه
FANCM: fork pause, rewind and play.
DNA lesions or genomic regions that are difficult to traverse frequently hinder or block DNA replication. In response to replication fork stalling, the cell activates the replication stress response pathway, which acts to protect the fork from collapse, promotes the repair or bypass of the blockage and facilitates the resumption of DNA synthesis. In this issue of the EMBO Journal, two studies c...
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Writing applications that connect to external services and yet remain responsive and resource conscious is a difficult task. With the rise of web programming this has become a common problem. The solution lies in using asynchronous operations that separate issuing a request from waiting for its completion. However, doing so in common object-oriented languages is difficult and error prone. Async...
متن کاملATR activation and replication fork restart are defective in FANCM-deficient cells.
Fanconi anaemia is a chromosomal instability disorder associated with cancer predisposition and bone marrow failure. Among the 13 identified FA gene products only one, the DNA translocase FANCM, has homologues in lower organisms, suggesting a conserved function in DNA metabolism. However, a precise role for FANCM in DNA repair remains elusive. Here, we show a novel function for FANCM that is di...
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Accurate and complete DNA replication is fundamental to maintain genome integrity. While the mechanisms and underlying machinery required to duplicate bulk genomic DNA are beginning to emerge, little is known about how cells replicate through damaged areas and special chromosomal regions such as telomeres, centromeres, and highly transcribed loci . Here, we have investigated the role of the yea...
متن کاملErase and rewind - Learning by replaying examples
Much of human learning is built on observing, retaining, and replicating behavior witnessed in a model. On this basis, instructors often teach informatics by providing programming examples to be observed and analyzed by learners. By retaining and replicating the steps leading to the final artifacts, students learn. However, professors usually illustrate an example program only once and provide ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2010
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2009.415